JMJD1A (Jumonji domain containing 1A), belongs to the JHDM2 histone demethylase family. Histone demethylase specifically demethylates 'Lys-9' of histone H3, thus play a central role in histone code. JMJD1A is involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 that are required for proper packaging and condensation of sperm chromatin.