Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase that is closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, hormones, and osmotic shock, etc. SGK has been involved in modulating anti-apoptotic and cell cycle regulation, as well as in activating certain potassium, sodium and chloride channels.