Bcl-rambo shares the common structural characteristics with other members of the anti-apoptotic Bcl-2 family members, but differs from them at its C-terminus, where a 250 amino acid sequence proceeds the membrance anchor region. It also differs from other pro-apoptotic Bcl-2 family members in that it membrane anchor C-terminus region is responsible for its apoptotic activity, not its Bcl-2 homology motifs.