The neuronal calcium sensor (NCS) protein binds to calcium throμgh EF-hand motifs, are expressed in neurons. They are implicated in the regulation of neurotransmitters released at the neuromuscular junctions. NCS-1 is widely distributed in the brain, spinal cord and dorsal root ganglia. It has been shown to regulate neurosecreation in a calcium-dependent manner, potentiates nitric oxide synthase activity. NCS-1 has been reserved to indicate the protein observed in humans and mammals.