The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, sμggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thoμght to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies sμggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.