The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data sμggests a potential role for TFF2 in acute and chronic asthma. Human TFF2 is a 12.0 kDa polypeptide of 106 amino acid residues.