High mobility group (HMG) protein 1 and 2 has been classified by DNA binding preferences and are ubiquitous non-histone components of chromatin. They bind to the minor groove of AT-rich DNA sequences with high affinity. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkB family, ATF-2 and c-Jun to activate transcription. HMG-2L1 (High mobility group protein 2-like 1), also known as HMGBCG, is a member of the HMG chromosomal protein superfamily. It contains a single HMG box DNA binding domain, and therefore does not contain an acidic C-terminal tail. HMG-2L1 is expressed in the nucleus and may play a role in transcriptional regulation.