Cell-permeable. A derivative of Staurosporine (Cat. No. 1048) that inhibits a variety of serine/threonine and tyrosine kinases including protein kinase C (PKC) IC₅₀ = 50 nM), cyclic AMP-dependent protein kinase (PKA) (IC₅₀ = 2.4 µM), S6 kinase (IC₅₀ = 5.0 µM), and EGFR (IC₅₀ = 3.0 µM). PKC412 reverses the efflux function of the multidrug resistance (MDR)-1 gene product, P-glycoprotein (P-gp).