A L-type calcium channel blocker and an anti-hypertensive agent. Amlodipine displays vasoprotective effects in cardiovascular disease and inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM). Amlodipin also inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).