A nootropic agent. NSI-189 stimulates new neuron growth in the hippocampus, a region of the brain believed to be implicated in MDD (major depressive disorder), as well as other diseases and conditions such as traumatic brain injury (TBI), Alzheimer's disease (AD), and post-traumatic stress disorder (PTSD). NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20%.