NDGA is a a phenolic compound isolated from the creosote bush Larrea divaricatta that has anti-cancer activities both in vitro and in vivo. NDGA acts as a non-selective lipoxygenase (LO) inhibitor (IC₅₀ values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO). Also inhibits IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.