AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.