WS6 is a novel Inducer of β cell proliferation. Inthe RIP-DTA mouse model of β cell ablation, WS6 normalizes blood glucose and induces concomitant increases in β cell proliferation and β cell number. Affinity pulldown and kinase profiling studies implicate ErbB3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6.