GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild type B-Raf and c-Raf with IC₅₀s of 3.2 nM and 5.0 nM, respectively.