MAFP is a potent inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀ = 2.5 nM). MAFP also binds to the CB1 receptor in rat brain membrane preparations (IC₅₀ = 20 nM). MAFP also acts as a selective, active-site directed, irreversible inhibitor of cPLA2 and iPLA2. It inhibits A23187-induced arachidonic acid release from human platelets with an IC₅₀ value of 0.6 µM. The IC₅₀ value for inhibition of iPLA2 from P388D1 cells is 0.5 µM.