A convenient set of five small molecules useful for generating human induced pluripotent stem cells (iPSC) from primary cells. The five products are: 1 mg of A-83-01 (Cat. No. 1725-1), 2 mg of PD-0325901 (Cat. No. 1643-2), 5 mg of PS48 (Cat. No. 1869-5), 1 g of Sodium Butyrate (Cat. No. 1609-1000) and 25 mg of Tranylcypromine hemisulfate (Parnate) (Cat. No. 1816-25).