A convenient set of five small molecules useful for self-renewal in stem cells and induced pluripotent stem cells (iPSCs). The five products are: 1 mg of A-83-01 (Cat. No. 1725-1), 5 mg of CHIR99021 (Cat. No. 1677-5), 1 mg of IQ-1 (Cat. No. 1663-1), 2 mg of PD-0325901 (Cat. No. 1643-2), and 500 µg of SU-5402.