A convenient set of four small molecule modulators (V6CT) useful for generation of iPSC’s (induced pluripotent stem cells) from mouse fibroblasts using a single gene, Oct4. The four modulators are: 200 mg of Valproic acid sodium salt (VPA) (Cat. No. 1647-200), 5 mg of CHIR99021 (Cat. No. 1677-5), 5 mg of RepSox (E-616452) (Cat. No. 1894-5) and 25 mg of Tranylcypromine Hemisulfate (Parnate) (Cat. No.1816-25).