A convenient set of six small molecule modulators (V6CTFZ) useful for generation of iPSC’s (induced pluripotent stem cells) from mouse somatic cells. The six modulators are: 200 mg of Valproic acid sodium salt (VPA) (Cat. No. 1647-200), 5 mg of CHIR99021 (Cat. No. 1677-5), 5 mg of RepSox (E-616452) (Cat. No. 1894-5), 25 mg of Tranylcypromine Hemisulfate (Parnate) (Cat. No.1816-25), 5 mgof Forskolin (Cat. No. 1531-5) and 1 mg of 3-Deazaneplanocin A (Cat. No. 2060-1000).