Potent endogenous ligand of the orphan G-protein-coupled receptor KISS1 (hOT7T175, AXOR12 and GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carcinomas. Stimulates gonadotropin secretion following i.c.v. administration.