Selective KCNQ2/Q3 potassium channel opener (EC50 = 0.69 μM). 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 with no measurable activity over a panel of cardiac ion channels (IC50 > 30 μM for hERG, NaV1.5, L-type channels and KCNQ1). Orally active in several animal models of epilepsy.